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KMID : 0357920010350020111
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Korean Journal of Pathology
2001 Volume.35 No. 2 p.111 ~ p.114
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Microsatellite Instability in Colorectal Carcinomas
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Cha Hee-Jung
Woo Dong-Kyun
Kim Sun-Hee
Kim Yong-Il
Park Jae-Gahb
Kim Woo-Ho
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Abstract
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Background: Microsatellite instability (MSI), which is caused by a deficient mismatch repair system, is seen in most of the hereditary non-polyposis colon cancers and a portion of sporadic colorectal cancers.
Methods: Two hundreds forty-six consecutive sporadic colorectal cancer patients were analyzed for MSI using an ABI 377 automatic sequencer and fluorescent dye-labelled primers (BAT-25 and BAT-26).
Results: The overall incidence of MSI in studied cases was 9.8% (24/246). This incidence is lower than most of the reported incidences in western countries. The incidence of MSI tumors in the proximal colon was 29.6%, while that of the distal colon was only 4.2% (p<0.001). MSI in sporadic colorectal cancers was more prevalent in poorly differentiated adenocarcinoma. In contrast to western countries, mucinous carcinoma did not show higher incidence of MSI.
Conclusions: The results suggest that MSI frequently occurs in cancers of the proximal colon and in tumors with poorly differentiated histology.
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KEYWORD
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Colorectal neoplasms, Microsatellite repeats, Sequence analysis
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